Soma (Carisoprodol): Uses, Dosage, Side Effects, Interactions

Common and Rare Side Effects for Soma Oral

What is Soma?

Initially approved by the FDA in 1959, Soma (Carisoprodol) is a midway acting muscle relaxant used in painful musculoskeletal conditions in association with exercise, physical therapy, and different prescription medications. This medication is available with or without prescription in an oral tablet or combined with anti-inflammatory medicine (aspirin), or in a fixed-portion blend with both ibuprofen and codeine and aspirin.

In January 2012, this medication was named a Schedule IV substance under the controlled substances act in a few US states because of a disturbing increase of misuse regardless of having a low potential for abuse, notwithstanding a generally safe of dependence.


Soma is demonstrated for the help of inconvenience identified with intense, painful musculoskeletal conditions.

Significant constraints of use: 

  • Should just be used for intense treatment periods up to a little while (2-3 weeks)
  • Any research has not established Adequate proof of viability and safety for increasingly prolonged use
  • Not suggested in pediatric patients under 16 years old


Soma is a centrally acting skeletal muscle relaxant that doesn’t demonstrate legitimately on skeletal muscle yet acts straightforwardly on the CNS or central nervous system. This medication eases the painful impacts of muscle fit or spasm. A metabolite of Soma, meprobamate, has both anxiolytic and narcotic or sedative properties. Clinical investigations demonstrate that this medication causes weakness of psychomotor execution in neuropsychological tests.

Mechanism of activity 

The mechanism of activity of Soma in calming uneasiness related to intense painful musculoskeletal conditions has no affirmation from any established research. In examines using creature models, the muscle unwinding prompted via Soma describes with an adjustment in the interneuronal movement of the spinal cord and the sliding reticular development, situated in the brain.

The abuse capability of this medication is credited to its capacity to modify GABAA work. This medication appears to regulate an assortment of GABAA receptor subunits. GABAA receptor adjustment can prompt anxiolysis because of inhibitory impacts on neurotransmission


The primary pathway of Soma’s liver digestion is by the cytochrome compound CYP2C19 to frame meprobamate. This compound shows hereditary polymorphism, which may influence the metabolism of this medication.

Route of elimination 

Soma gets eliminated by the kidneys as well as other different courses. The half-existence of meprobamate is roughly 10 hours.


The terminal half-life of soma is roughly 2 hours.


Taken at prescribed doses, soma creates therapeutic benefits within 30 minutes of intake. These effects lasting for about four to six hours include:

  • Relaxed muscles
  • Reduced muscle spasms
  • Drowsiness

At higher than prescribed doses, soma leads to a euphoric high. Effects of the high include:

  • High sensations of well-being and self-confidence
  • Increased socialization
  • Increased energy
  • Hallucinations
  • Elevated mood

Combining soma with other central nervous system-depressing drugs like alcohol, opioids, or benzodiazepines may increase these effects.


Although soma is generally safe to use when taken as prescribed, yet there are some potential side effects of the medication. These include:

  • Headaches
  • Dizziness
  • Vomiting
  • Drowsiness
  • Clumsiness
  • Fast heart rate
  • Hallucinations
  • Amnesia

The most significant risk associated with soma is an overdose.


An overdose of Soma prompts CNS depression, and in extreme cases, induction of a state of extreme lethargy or coma. Depression of respiratory functions, shock, seizures, and death have likewise been accounted for in uncommon cases. A few side effects might be related to Soma overdose, for example, horizontal and vertical nystagmus, mydriasis, blurred vision, mild tachycardia and hypotension, euphoria, respiratory depression, CNS stimulation, muscles incoordination, and additionally inflexibility, rigidity, headache, confusion, hallucinations, and dystonic responses.

Alcohol or different CNS depressants or psychotropic agents can apply added substance consequences for Soma in any event, when one of the agents has been ingested at the typical, helpful dose. Lethal inadvertent and non-incidental overdoses have both been accounted for with Soma ingestion alone or ingestion of Soma in the mix with alcohol or psychotropic medications.

Dependence and withdrawal

In the postmarketing reports after Soma use, instances of dependence, withdrawal, and misuse have been accounted for with long term use. Most dependence and withdrawal cases, just as misuse, have happened in patients with a background marked by dependence or who have used this medication in a mix with different medications having misuse potential. Be that as it may, various post-showcasing antagonistic occasion reports have been made of carisoprodol-related abuse when used without different drugs having misuse potential.

Withdrawal indications have been watched and announced after the unexpected sudden end after long term use. To diminish the chances of dependence, withdrawal, or misuse, the medication should be used with alert in habit inclined patients and patients taking different CNS depressants, including alcohol. Soma should not be taken for longer than 2 to 3 weeks for symptomatic help of intense musculoskeletal discomfort.

Use in pregnancy 

This medication has been named Pregnancy Category C. There is no preliminary clinical information on the use of Soma during human pregnancy. Creature contemplates showing that Soma crosses the placenta and prompts unfavorable impacts on fetal development and postnatal survival. In postmarketing reports, the principal metabolite, meprobamate, has not exhibited a positive relationship between maternal use and an expanded hazard for explicit intrinsic deformities.

Use in nursing 

Constrained information in people shows this is found discharged in human breast milk and may arrive at concentrations in human milk of 2-4 times the maternal plasma focuses. It is along these lines prudent to practice alert when this medication is used during breastfeeding.


Recreational users, at times, blend Soma in with different medications or alcohol to upgrade the calming and relaxing properties of the two substances. Some compound types of Soma as of now contain codeine, a narcotic painkiller, so joining Soma with different narcotics is particularly risky.

The danger of overdose rises necessarily when users mix Soma in with various substances that discourage certain vital elements of the central nervous system, for example, breath and pulse. Antidepressants, alcohol, narcotics, and benzodiazepines, for example, Valium or Xanax, all increase the danger of an overdose when taken with Soma.

An examination directed by the Substance Abuse and Mental Health Services Administration (SAMHSA) found that in crisis room visits identified with Soma, 77% of cases included other physician recommended drugs: 55% included narcotics, and 47% included benzodiazepines. Moreover, 12% of Soma-related ER visits likewise included alcohol.

Taking Soma in with different medications has become so well known that there are even slang terms for this practice. “Soma Coma” is the road name for Soma blended in with codeine, while Soma mixed with Vicodin is called the “Las Vegas Cocktail.” Notwithstanding the danger of overdose and other wellbeing intricacies, users who misuse Soma alone or in blend with different medications face a threat of creating drug-seeking, compulsive, sedate looking for practices that could prompt addiction.


Addiction is an interminable condition in which an individual continues searching out and using drugs, notwithstanding encountering actual negative results from doing so. With numerous sorts of substance dependence, changes happen in mind after some time that makes it hard for the individual to control their impulse to use the medication.

Addiction is now and again attached to the double procedures of resilience and dependence. As resilience or tolerance builds, individuals discover they have to take increasing measures of the medication to accomplish the ideal reaction. As the patterns of Soma abuse heighten, critical physical dependence is nearly ensured to create, and when it does, the body will become so used to the nearness of the medication that it needs it to feel normal. An individual who is genuinely subject to Soma will encounter withdrawal manifestations if they unexpectedly quit using it.

Building up some level of either tolerance or dependence doesn’t mean an individual is addicted to Soma; however, they are connected. Somebody dependent on Soma will continue taking the medication despite genuine physical, social, or mental consequences. Someone might be determined to have a habit on the off chance that they involvement with at least 2 of the accompanying signs and symptoms over a time of a year or less:

  • Taking Soma over a more drawn out timeframe or in more prominent doses than expected
  • Needing to curtail, or attempting to reduce use, however not having the option to do as such
  • Encountering strong desires to use Soma
  • Investing a ton of energy and time trying to get Soma, taking Soma, and recuperating from using Soma
  • Performing inadequately at work or in school, or ignoring family duties due to medication use
  • Using the medication although it makes strife with family or companions
  • Using Soma in risky circumstances, for example, when driving
  • Proceeding to take the drug even though it creates a clinical or mental condition
  • Building up a resilience or tolerance to Soma
  • Encountering physical withdrawal when medication use is halted or diminished

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